Clinical Update on Optimal Prandial Insulin Dosing Using a Refined Run-to-Run Control Algorithm

Clinical update on optimal prandial insulin dosing using a refined run-to-run control algorithm.

BACKGROUND This article provides a clinical update using a novel run-to-run algorithm to optimize prandial insulin dosing based on sparse glucose measurements from the previous day's meals. The objective was to use a refined run-to-run algorithm to calculate prandial insulin-to-carbohydrate ratios (I:CHO) for meals of variable carbohydrate content in subjects with type 1 diabetes (T1DM). METH...

A run-to-run framework for prandial insulin dosing: handling real-life uncertainty

Individuals with type 1 diabetes require frequent adjustment of their insulin dose to maintain as near to normal glycaemia as possible. This process is not only burdensome but also, for many, difficult to achieve. As a result, control algorithms to facilitate insulin dosage have been proposed, but have not been completely successful in normalizing glycaemia. Here we present a novel run-to-run c...

Prandial insulin dosing using run-to-run control: application of clinical data and medical expertise to define a suitable performance metric.

OBJECTIVE We propose a novel algorithm to adjust prandial insulin dose using sparse blood glucose measurements. The dose is adjusted on the basis of a performance measure for the same meal on the previous day. We determine the best performance measure and tune the algorithm to match the recommendations of experienced physicians. RESEARCH DESIGN AND METHODS Eleven subjects with type 1 diabetes...

Run-to-run control methods based on the DHOBE algorithm

Many run-to-run (RtR) control methods have been developed in recent years. Two particular set-valued RtR control schemes based on the Dasgupta-Huang Optimal Bounded Ellipsoid (DHOBE) algorithm are introduced. Compared to other RtR control schemes, the methods in this paper only need to know the bound of the noises, and are easy to implement. The DHOBE algorithm, for each recursion, returns an o...

Run-to-Run Control in Semiconductor Manufacturing